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Boss Stem Cell

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"Boss Stem Cell"
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Details
Source
The Hand of the King and The Giant

Boss Stem Cells (or simply Boss Cells) are permanent items that increase the difficulty of the game when active. The first one is acquired by beating the Hand of the King with no Boss Stem Cells active, the second by beating him with one active, and so on. However, the fifth Boss Stem Cell is obtained by beating the Giant with four active.

Boss Stem Cells can be injected and removed at the start of the game in the Tube. Each one makes the game significantly harder by increasing enemy tier, density, variety, and limiting healing options. On the other hand, higher difficulty levels also increase cells dropped from enemies and the level of the Legendary Forge, and allow access to new blueprints and bonus doors scattered through the levels. The doors show the number of Boss Stem Cells required to enter and shine blue if enough are currently active. The fifth Boss Cell is special in that it doesn't modify anything compared to the fourth until the Throne Room, where it grants access to a secret biome, the Astrolab, and the hidden final boss of the game in the Observatory.

Modifiers[edit | edit source]

# of Boss Stem Cells Modifiers
Boss Stem Cell.png
- Hard difficulty

- Reduce number of health fountains (only available every other level); transition areas without health fountains will instead give a mini recharge that will refill one use of health flask

+ Improves the level of the Legendary Forge by allowing you to increase the frequency of ++ items up to 100%

+ Unlocks a door in Prison Depths that goes to the Ancient Sewers

+ Allows you to collect the next Boss Stem Cell

2 Boss Cells.png
- Very Hard difficulty

- Removes all health fountains, but gain one mini recharge after each boss

+ Improves the level of the Legendary Forge by allowing you to increase the frequency of S items up to 25%

+ Multiplies the amount of dropped cells by 2 (effect also applies to cells found in containers)

+ Unlocks a door in Slumbering Sanctuary that goes to the Cavern

+ Unlocks a door in Forgotten Sepulcher that goes to Guardian's Haven

+ Allows you to collect the next Boss Stem Cell

3 Boss Cells.png
- Expert difficulty

- Removes all health fountains (individual flask recharges can only be bought in Food shops)

+ Improves the level of the Legendary Forge by allowing you to increase the frequency of S items up to 50%

+ Multiplies the amount of dropped cells by 2 (effect also applies to cells found in containers)

+ Improves Legendary items by having them grant +1 to all Stats

+ Unlocks a door in Ramparts that goes to the Insufferable Crypt

+ Allows you to collect the next Boss Stem Cell

4 Boss Cells.png
- Nightmare difficulty

- Removes all health fountains (individual flask recharges can only be bought in Food shops)

- Taking hits always causes Malaise

- Increases detection range of mobs and gives most of them the ability to teleport next to your position

- Some of the food found in levels is infected by the Malaise

+ Improves the level of the Legendary Forge by allowing you to increase the frequency of S items up to 100%

+ Improves Legendary items by having them grant +1 to all Stats

+ Multiplies the amount of dropped cells by 3 (effect also applies to cells found in containers)

5 Boss Cells.png
- Hell difficulty

- Removes all health fountains (individual flask recharges can only be bought in Food shops)

- Taking hits always causes Malaise

- Increases detection range of mobs and gives most of them the ability to teleport next to your position

- Some of the food found in levels is infected by the Malaise

- No Collector in transitions areas (collected blueprints are unlocked when you go past where Collector was standing)

+ Improves the level of the Legendary Forge by allowing you to increase the frequency of S items up to 100%

+ Improves Legendary items by having them grant +1 to all Stats

+ Multiplies the amount of dropped cells by 3 (effect also applies to cells found in containers)

+ Gives access to the Astrolab and the Observatory (Rise of the Giant DLC content)

Doors[edit | edit source]

Notes[edit | edit source]

  • Until v1.2, the fifth boss cell was unobtainable, and a 5 BSC door in the Graveyard would grant access to the unfinished level Repository of the Architects.


Navigation wiki

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PickupsObjectsBoss Stem CellMalaiseOutfitsCursed chests
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