Keepers are the bosses in Dead Cells. Each keeper has their own biome, where the player must defeat them to progress. Currently the player can defeat only three of the five bosses per run on 0 to 4 BSC difficulty levels. On 5 BSC difficulty the player can defeat four of the six keepers.
There are currently six keepers in the game: The Concierge, Conjonctivius, The Time Keeper, The Giant, The Hand of the King, and The Collector.
As the first boss, the player may find one of these two, depending on the path that they take.
The first boss encountered in the game, as it requires only the Vine Rune to be reached. Found in the Black Bridge. Must be defeated to reach the Stilt Village.
Can be reached by going through the Toxic Sewers, then the Ancient Sewers, to the Insufferable Crypt.
The player must have absorbed both the Vine Rune and the Ram Rune in order to take this path.
Found in the Clock Room. Can be reached through either the Clock Tower or the Forgotten Sepulcher.
Found in the Guardian's Haven. Must be reached through the Cavern on the first meeting, can be reached via a 2 BSC door in Forgotten Sepulcher afterwards.
The final boss of the game on 4 BSC and less. Found in the Throne Room. Can only be reached through High Peak Castle, there are no alternate paths after the Clock Room or Guardian's Haven.
The true final boss of the game. Found in the Observatory, which can only be reached with 5 BSC active, after the Throne Room and the Astrolab.